1) IDF Diabetes Atlas Ninth edition 2019
3) McCrimmon, R.J. and R.S. Sherwin, Hypoglycemia in type 1 diabetes. Diabetes, 2010. 59(10): p. 2333-2339.; Frier, B.M., The incidence and impact of hypoglycemia in type 1 and type 2 diabetes. International Diabetes Monitor, 2009. 21(6): p. 210-218.
Both forms of diabetes eventually result in β-cell failure and chronic hyperglycaemia:
- Type 1 diabetes (T1D) corresponds to an autoimmune disorder wherein the β-cells are selectively destroyed;
- Type 2 diabetes (T2D) is caused either by a loss of function of the β-cells or a resistance to insulin action in the peripheral target tissues (liver, muscle, adipose, etc.).
The goal of diabetes therapies is to maintain a normal blood glucose level and reduce cardiovascular risk factors.
While current therapeutic approaches for T1D (insulin supplementation, islet transplantation) save lives, cardiovascular complications often impact the overall life expectancy of diabetic patients, and alter quality of life.
Our lead drug candidate is a novel recombinant protein, intended to regenerate functional pancreatic islets and to slow down the progression towards beta-cell failure.
The company leverages the know-how and expertise from the laboratory of Dr Patrick Collombat (Inserm, CNRS, Nice University) on pancreatic beta-cell and a large network of experts, from preclinical to clinical, covering notably protein engineering, diabetes pharmacology and translational research.
Despite currently available therapies, a still intolerable number of diabetic patients develop severe complications over time. Our goal is to restore an endogenous production of insulin, and thus an improved glycemic control for these patients.
Dr Patrick COLLOMBAT
It is ninety-nine years since Leonard Thompson became the first person with Type1 Diabetes Mellitus to be injected with insulin. His life was saved, and to this day around the globe, for millions of people with T1DM life is maintained with exogenous insulin. The challenge of averting a very early death had been met, and a new challenge emerged, to avoid the microvascular complications associated with higher blood sugar levels while also avoiding the dangers of hypoglycaemia, blood sugars that are too low. At DiogenX the team are excited by and committed to the mission of restoring endogenous insulin function and taking the Type 1 diabetes community off this complex tightrope between competing dangers in their daily lives.
Chairman of the Board
180 avenue du Prado
Institut de Biologie Valrose
Parc Valrose – Centre de Biochimie
06108 Nice cedex 2